The article deals with transformation of the National University of Singapore (NUS) in the entrepreneurial university, international educational and innovation hub, capable to generate 8% of Singapore GDP, to be the third patent holder in the country, to create more than 250 patents annually. The authors analyze the activities of the university innovative infrastructure objects, as well as innovative physical, financial and service infrastructure of the University. Article materials are interesting not only for researchers, but are also of practical interest, they will be useful both for managers of higher education institutions and for a wide range of academic researchers studying the topics of academic entrepreneurship.

The article focuses on the transformation of the Russian higher education system to meet the latest market economy demands and to develop the efficient interaction with the business community. Universities are integrating into existing production chains and new markets. Leading Russian universities are being transformed into innovation hubs, playing the role of integrators in scientific and technical processes, developing efficient mechanisms of technology transfer, they are able to form new educational programs that meet the latest demands of the knowledge society. Nationally oriented system of higher education based on traditional values and meeting institutional requirements of the country’s ecosystem, should become an important factor of Russia’s stable development.

The paper investigated the current state of innovation system in France. By the example of the Higher School of Engineering École Polytechnique it considers formation of technology transfer center as a link between university innovation activity and entrepreneurial activity of major national corporations in France. The article examines principles of interaction between the major players of the university innovation system and their role in supporting small innovative companies formed as a result of the university innovative activity.

The article deals with the current state of innovation system in Israel. The article presents approaches of the Israeli innovation system major players to the issue of technology transfer and innovation support. The paper considers the Israeli government policy aimed at the innovations commercialization support by the example of the Weizmann Institute.

Just the university sector is called to play a key role in formation of the Russian innovation system.